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Initial results of the Phase 3 ESSENCE trial looking at the effect of semaglutide on liver disease were released at the November 2024 American Association for the Study of Liver Diseases meeting

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One major concern is that chronic use of GLP-1 RAs may create a supraphysiological state of GLP-1, leading to gastrointestinal upset, pancreatitis, or excessive stimulation of pancreatic activity

Patients interested in precision-informed GLP-1 selection can share Precision Peptide Genetic Test results with their prescriber to support more tailored conversations about starting dose, titration pace, and which compound (semaglutide, tirzepatide, or dual-compound protocols) may align best with their individual biology and goals