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Growing clinical experience with amylin analogues has clarified the hormones importance as part of the integrated network governing body weight and metabolic homeostasis

Taylor SW, Nikoulina SE, Andon NL, Lowe C (2013) Peptidomic profiling of secreted products from pancreatic islet culture results in a higher yield of full-length peptide hormones than found using cell lysis procedures

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For individuals with Wilson's disease (a genetic disorder causing copper accumulation) or other copper metabolism disorders, theoretical caution is warranted, though even in these populations topical GHK-Cu is unlikely to pose significant risk given the minimal systemic absorption