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59 Scientific evidence indicates that not necessarily the deficiency but the low status of the B 12 biomarker has been associated with increased total Hcy level, which is involved in increased generation of reactive oxygen species in lipid peroxidation and tissue damage to the endothelium vascular and thromboembolism

Vitamin B12 deficiency is genuinely common in older adults, up to 43% of adults over 65

Research with senescent rhesus monkeys (aged 20-27 years) showed that Epithalon administration decreased basal plasma levels of glucose and insulin while increasing basal nighttime melatonin levelsreversing age-associated endocrine dysfunction patterns

Clinical studies have demonstrated that these medications can produce additional weight loss in post-bariatric patients who have experienced weight regain or inadequate initial weight loss