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Some may be effective only in systemic but not topical applications (propranolol, acetazolamide) [34]

Manufacturing is unregulated Solvent residues may remain Purity is unverified Sterility is not assured 3

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Note: For complete details, please review product monographs at and regularly review current Health Canada advisories, warnings and recalls at: for the most up to date information.) Table 4: Treatment of B 12 deficiency (adapted from Means 2021) 27 Note: Intranasal administration is generally not used