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"Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and suicidality: A replication study using reports to the World Health Organization pharmacovigilance database (VigiBase)." Journal of Affective Disorders, 2024

Possibly due to the ability of GPx-4 to reduce these membrane-associated hydroperoxides, it is the only subtype of mammalian GPxs for which the knockout is lethal (320), but the precise cause of the midgestational lethality caused by GPx-4 deficiency (401) is unknown, and may be unrelated to the reduction of phospholipid hydroperoxides by GPx-4

Doing so may carry a potential risk of overdose and serious side effects

This characteristic leads to negligible alterations in osmotic pressure and culminates in cell death that is independent of cellular lysis [26]