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Where to apply tretinoin cream Tretinoin is safe to apply to most areas of your face prone to wrinkling: Around the eyes (crows feet) Around the lips (smile lines) Between the eyebrows Cheeks Chest Chin Forehead Neck Tip: The lips and nostrils are more sensitive to retinoids, so dont apply tretinoin directly or too close to these areas

10.1038/nature742 41 EralyS

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