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Synergistic effects of baicalein with ciprofloxacin against NorA over-expressed methicillin-resistant Staphylococcus aureus (MRSA) and inhibition of MRSA pyruvate kinase

Hence, the use of combination therapies to target multiple metabolic pathways to suppress tumor growth may be most effective, especially in identifying cases that induce synthetic lethality, where two drugs induce cell death in combination, but not individually

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2025), providing evidence that ascorbate and glutathione pools are redox-coupled in vivo and that the pathway can operate in different modes depending on flux and the relative capacities of these two reductases (Fig