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[1] [2] Clinical trials have demonstrated robust efficacy, with A1C reductions of 1.9% to 2.4% and weight loss of approximately 15% at 5 mg and 20-21% at 10-15 mg of baseline body weight in the SURMOUNT-1 trial

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The high doses of vitamin E, which can cause renal effects, were compared to upper limits of toxicity (UL) as established by various authorities worldwide