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In terms of metabolic parameters, all the treated arms had beneficial changes in their HbA1c%, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) levels, with the Sema+-MSTN+-ActA arm, which showed the largest combination of fat decrease and lean mass increase, showing the biggest beneficial changes (Fig

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Notwithstanding, in pharmacokinetic studies, patients with moderate or severe hepatic impairment showed no increase of drug exposure after administration of multiple doses of linagliptin, compared to normal controls