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Unlike BCTC, exendin 939 also mitigated both thermal and mechanical nociceptive behaviors in mice without inducing hyperthermia, indicating that it is a viable analgesic without the common adverse effects associated with existing pain management strategies, such as opioids and traditional TRPV1 antagonists 32,42,51,52,53

One of the central regulators in this process is hypoxia-inducible factor-1 alpha (HIF-1), a transcription factor that senses low oxygen levels and triggers the expression of genes involved in angiogenesis, metabolism, and cell survival

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Animal models of AD, PD, ischemic stroke, ICH, HD, MS, ALS, depression, epilepsy, and SCI have all shown benefits following GLP-1 receptor agonist treatment