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[11] Who Should Not Use This Stack Several populations should avoid Ipamorelin entirely or use it only under close specialist supervision: Active or prior history of any GH-sensitive malignancy (e.g., pituitary adenoma, prostate cancer, colorectal cancer) Diabetic patients with poor glycemic control (HbA1c above 8%) Pregnancy or breastfeeding (no safety data) Pediatric patients with open epiphyses (risk of disproportionate bone growth) Wilson's disease or other copper metabolism disorders (GHK-Cu contraindicated) The FDA has not approved Ipamorelin or GHK-Cu for any human therapeutic indication