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These changes were statistically significant, and the direction of effect suggests possible neuroprotection, but the magnitude was very small (particularly if we compare these results to those in the Phase 3 trials of AD drugs that are now approved, such as lecanemab or donanemab) , the sample limited, and there is no evidence these shifts translate into meaningful clinical benefit

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The STEP 1 trial studied semaglutide 2.4 mg weekly in adults without diabetes and found 14.9% mean body weight loss versus 2.4% with placebo at 68 weeks