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Taking 1 mL working solution as an example, add 100 L DMSO stock solution ( 50.0 mg/mL ) to 900 L 20% SBE--CD in Saline, and mix evenly
By reducing the levels of these hydroperoxides, GPX4 inhibits the formation of more reactive and damaging lipid radicals, particularly protecting cells with membranes rich in PUFAs, which are highly susceptible to peroxidation (143,146)
Although it affected body composition, it did not reduce bone mineral density, weaken mechanical strength, or increase marrow adipocytes in the same way as SAAR
These fragments stimulate inflamed synovium cells (synoviocytes, macrophages, lymphocytes) to secrete cytokines, chemokines, and lipid mediators, as well as more ROS and MMPs, which can directly degrade the components of the cartilage matrix or dysregulate the metabolism of chondrocytes, leading to an imbalance between cartilage matrix degradation and synthesis
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