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[3] [4] This metabolic involvement has led some to speculate about a connection between B12 and energy or fat metabolism a claim that warrants careful scrutiny

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In ApoE / mice that are given a HFD, the persistent activity of the SNS exacerbates oxidative stress in ECs by increasing blood levels of norepinephrine and the activity of mitochondrial monoamine oxidase A (MAO-A), culminating in mitochondrial dysfunction and inflammatory responses