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Of note, the rate of premature treatment discontinuation due to AEs was comparable between genders, suggesting that the higher reported occurrence of GI AEs in women did not result in increased drug discontinuation

Menopause triggers a metabolic shift that makes weight gain nearly inevitable for most womenstudies show the average gain is 5 pounds during the transition years

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The answer to the first question is that he first performed a preliminary study with a wider range of doses, reported in the same paper