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Treatment of the proteins with DTT prior to application to the array allowed us to distinguish between those proteins where BioGEE had been incorporated into the protein via a non-disulphide mechanism (possibly due to interaction with biotin) from those that formed disulphide bonds with the GSH in BioGEE and hence were more likely to represent potential targets of glutathionylation

Challenges remain, like balancing supplementation to avoid toxicity, but the potential for personalized medicine based on GPx profiles excites researchers

These findings suggest that therapies capable of blocking glutathione transport into organelles within the cell could help treat breast cancer

Available at: 199 VendraminV.VielA.VincenziS