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How Tirzepatide Works to Trigger Early Weight Loss Tirzepatide mimics the actions of two natural gut hormones: glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)

This phosphorylation of cGAS promotes the K48-linked poly-ubiquitination of cGAS which interacts with autophagy receptor p62 for autophagic degradation in autolysosome

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2.2 Molecular physiology of GIP and GLP-1 GIP and GLP-1 concentrations appear to be highly variable among individuals, both with and without T2DM