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However, in GDH 1 knock-out mice (only humans express GDH 2) most functions, except the already mentioned reduced glutamate oxidation in cultured astrocytes, are remarkably intact (Frigerio et al., Table 2 Oxygen consumption rates as indications of kinetics of glutamate-dehydrogenase and aspartateglutamate transferase activities in non-synaptic mitochondria from the rat

Individuals most likely to benefit include: Those with pernicious anemia People with gastrointestinal disorders (e.g., Crohns disease, celiac disease, chronic gastritis) Patients following bariatric (weight loss) surgery Older adults with absorption difficulties Strict vegetarians or vegans at risk for deficiency People taking medications that can decrease vitamin B12 levels Laboratory testing usually confirms B12 deficiency before starting injections

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