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Iron and copper ions leaking from process equipment are prooxidative and hence catalyse the oxidation of folates 66,223

The matrix metalloproteinases responsible for breaking down collagen in damaged veins

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3.2 Lipid accumulation Lipid accumulation is a common feature in the tubular cells of patients with DKD ( Lipotoxicity in renal TECs is associated with inflammation, oxidative stress, mitochondrial dysfunction and cell death ( Hypercholesterolemia also results in lipid deposition in kidney tissue, further compromising oxygen delivery through diffusion ( 3.3 Hypoxia Renal hypoxia has been observed in animal models of diabetes ( The enormous oxygen consumption in the kidneys is largely due to tubular reabsorption