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GLP-1 Receptor Agonists, Obesity, and Cardiovascular Disease Glucagon-like peptide-1 receptor agonists (GLP-1RAs) were originally developed to improve glycemic control in type 2 diabetes but have since demonstrated benefits in weight reduction and cardiovascular risk modification, including in people without diabetes

It is also indicated to reduce the risk of heart attack and stroke in adults who have cardiovascular disease and have obesity or overweight

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In addition to being the natural incretin hormone that regulates blood sugar, GLP-1 is also a recognized neurotransmitter whose receptors are expressed in many regions of the brain