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Description

Beyond intestinal soapbile acids in metabolic control

Plasma DPP-4 activity ( A and C ), plasma TG and AUC over 180 minutes ( B and D , left and middle), and plasma levels of active GLP-1 before and 10 minutes after oral gavage of olive oil ( B and D , right) during a lipid tolerance (LTT) in response to water or a gut-selective (14 g/mouse) or systemic (10 mg/kg) dose of sitagliptin in 10- to 13-week-old Dpp4 Gut+/+ ( A and B , n = 1421/group) and Dpp4 Gut/ ( C and D , n = 719/group) mice fed a regular chow (RC) diet

Protocol: an average of 4 to 6 sessions