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Given the differences in the MedDRAs categorization rules, some potential PTs that were not included may exist, e.g., depression suicidal (belonging to HLGT level, depressed mood disorders and disturbances) and intentional overdose (belonging to HLGT level, overdoses, and underdoses NEC)

Moreover, the WD model creates an unfavorable environment in the gut and alters the functions of the intestinal barrier and microbiota composition, leading to dysbiosis and inflammation [188]

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