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The translational pathway would benefit from early thoughts from materials science, clinical, and regulatory experts to co-design delivery formats (e.g., special nanocomposite antimicrobial coatings that rapidly kill persisters on catheters) and to co-plan staged clinical trials with microbiological markers of success (i.e., MBEC reduction and no relapse) and not just surrogates of colonization

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31,32 The primary site of impact is the small intestine, where poor absorption of various nutrients including vitamin B 6 can occur

Jumping directly to 10 mg would likely cause severe gastrointestinal side effects and is not recommended under any circumstances