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By working collaboratively across the ecosystem, we help ensure that consumers have access to safe and effective solutions and medications. The End of the GLP-1 Shortage In October 2024, the FDA announced that the shortage of tirzepatide, the active ingredient in Mounjaro and Zepbound, was resolved, and shortages of other GLP-1s are also poised to be resolved in the near future

Furthermore, GLP-1 agonists preserve mitochondrial integrity, reduce endoplasmic reticulum stress, and inhibit cardiomyocyte apoptosis through activation of the PI3K/Akt and AMPK pathways [82]

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