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When thinking of gout, a useful model has been proposed by Wortmann.1 Uric acid crystals can be thought of like matches, which can sit quietly or can be ignited

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Despite their considerable therapeutic potential, the exact mechanisms underlying EV-mediated cardiac regeneration remain incompletely understood, reflecting the intricate interplay between their heterogeneous cargo, recipient cell specificity, and the evolving postischemic tissue microenvironment

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