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Nausea is the most common side effect and is usually transient, peaking during dose titration and fading within a few weeks

47,48 GLP-1 agonists impact the dopamine signaling in the mesolimbic pathway and regulate the reward-motivated behavior in alcohol consumption, thus showing potential as a pharmacotherapeutic intervention

Although these studies failed to observe sickness upon activation of PPG neurons in the NTS in mice, a study in rat observed conditioned taste aversion upon injection of GLP1 into the central amygdala, but not into the paraventricular nucleus of the hypothalamus (Kinzig et al., 2003)

With these facts in mind, asking a doctor if semaglutide GLP-1 is a viable option for you will be a great step for people looking for an effective weight loss treatment