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These combined effects help regulate blood sugar levels and reduce appetite, making it easier to control portions and resist overeating

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demonstrated that semaglutide modulates the circulating proteome in individuals with overweight or obesity, with or without diabetes [67]

Consequently, GIP and GLP-1 receptor agonists exhibit complementary and potentially synergistic actions, suggesting that their combined administration may further enhance glucose regulation and support weight reduction.1113,50 This rationale underpins the development of dual GLP-1/GIP receptor agonists, which have been proposed as super-GLP-1 receptor agonists because of GIPs capacity of GIP to potentiate GLP-1 effects.48,51 Clinical Pharmacology of GLP-1RAs The incretin effect of GLP-1RAs was initially characterized by the observation that oral glucose administration elicits a proportionally greater and more sustained insulin secretion compared to an equivalent intravenous glucose dose.52,53 This incretin effect, which accounts for approximately two-thirds of the total insulin secretion during an oral glucose tolerance test, is diminished in individuals with T2DM