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In preclinical models, co-administration of bimagrumab or dual myostatin/activin A inhibitors with GLP-1R agonists preserves or increases muscle mass while enhancing fat loss, resulting in improved body composition and metabolic outcomes compared with GLP-1R agonist monotherapy [176]

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Context Rheumatoid arthritis (RA) is a chronic autoimmune disorder affecting approximately 0.5 - 1% of the global population, with a prevalence of 1 - 2% in women aged 40 - 60 years (1)