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Eric Verdin, in a review published in Science (2015), documented NAD+ depletion across aging tissues and its downstream effects on sirtuin enzyme activity, PARP-mediated DNA repair, and mitochondrial function

10.1016/j.bbadis.2025.167987 [DOI] [PubMed] [Google Scholar] Teran E., Hernndez I., Tana L., Teran S., Galaviz-Hernandez C., Sosa-Macas M., et al

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Patients also experienced a significant reduction in systolic blood pressure ( p = 0.002) and hepatic enzymes alanine transaminase (ALT) and aspartate transaminase (AST) (respectively, p = 0.0008 and p = 0.004), consistently with the significant weight loss obtained (Fig