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The main differences between the two come down to available medications, dosing flexibility, and how much behavioral support is included with each plan

Redifferentiation therapy may use tyrosine kinase inhibitors, which include: BRAF and MEK inhibitors such as dabrafenib or trametinib RET and NTRK inhibitors such as selpercatinib or larotrectinib Patients with advanced disease or disease that comes back may consider enrolling in a clinical trial

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It is well established that all three medications are effective at lowering blood glucose, but only SGLT2 inhibitors and GLP-1 agonists have established additional benefits at reducing cardiovascular and kidney outcomes, Peter Hanlon, PhD, clinical senior research fellow at the University of Glasgow in Scotland, United Kingdom, and corresponding author on the review paper, told MNT