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The elderly (reduced absorption) Pernicious anemia Vegetarians / Vegans (low dietary B12) People taking metformin or acid reflux medications (PPIs) Post-bariatric or gastric-bypass patients Genetic variants in MTRR , MTR , or TCN2 What Has B12 Been Studied For

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Phosphatidylserine (PS), as a phospholipid of the renal tubular epithelial cell membrane that can adsorb crystals, flips to the cell surface, enhancing the adhesiveness of stone crystals at the flipped sites ( Joshi et al