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Further prolongation of 6-substituted sulfonohydrazide derivative to sulfonyl-N-substituted hydrazine-1-carbox(thio)amide, developing several corresponding derivatives of 29 with IC50 values ranging from 0.0390.068 nM and binding within an active pocket of DPP-4 protease with an additional interaction which tend to increase the potency of the synthesized derivatives 29A , 29B , 29G , 29F of specified class however, 29D and 29H ascertained to lost their inhibition potency against DPP-4 holding p-chlorophenyl and p-methoxyphenyl derivatives

Maresin1 protect against ferroptosis-induced liver injury through ROS inhibition and Nrf2/HO-1/GPX4 activation

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