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Am J Obstet Gynecol 2007;197:404, e1-5

Male homozygous for the polymorphism of PPP1R3A gene that involved in glycogen synthase activity are significantly younger at diagnosis than female

Intramuscular hydroxocobalamin injections represent the standard first-line treatment in the NHS: For deficiency without neurological involvement : Initially 1 mg three times weekly for two weeks, followed by maintenance injections every two to three months lifelong (if the underlying cause cannot be corrected)