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Incretin hormones are secreted in response to nutrient intake, with glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1) released from the upper and lower small intestines, respectively 4

Similarly, a 2025 retrospective trial in 312 deficient children showed sublingual methylcobalamin (5001,000 mcg/day) boosted B12 from a median 172 ng/L to 438 ng/L in just 1.5 months, rivaling injections without needles