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The treatment in ob/ob or db/db mice with higher dose (0.03% of diet) for 34 weeks also showed no effect on the body weight or intake of food

Hexarelin has been studied for cardioprotective signaling activity in preclinical models that persists independent of growth hormone receptor blockade, suggesting a CD36-mediated cardiac binding mechanism under separate investigation

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Post-operatively the animals were housed individually in an American Accreditation for Laboratory Animal Care-approved vivarium maintained at 221 C on a 12-h alternating light/dark cycle initiated at 06:00 h