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In children with growth failure outside the context of a clinical trial." [7] Off-Label Prescribing and Informed Consent in Minors Off-label prescribing is legal for adults and children alike, but the informed-consent standard is higher when the patient is a minor and the drug lacks any approved labeling

Several pathologies that affect the brain and kidneys have been associated with dysbiosis of the gut microbiota, and compared to the general population, individuals with CKD have a higher propensity for cognitive impairment (Drew et al., 2019)

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93 In their model, cydD mutants had reduced trimethoprim uptake, which was reversed by deleting acrAB or by restoring GSH (74)