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Using Tirzepatide resulted in a weight loss of 17.8% (95% CI: 16.3%-19.3%) compared with 12.4% (95% CI: 11.5%-13.4%) for Semaglutide. (Sackler Faculty of Medicine)

It works as a sympathomimetic amine, essentially a stimulant that suppresses appetite through norepinephrine release in the hypothalamus

The low pH of vitamin C and strong acids can destabilise the peptide, and combining with retinoids in a single routine often produces unnecessary irritation

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