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75 It seems plausible that severe vitamin B 12 deficiency can also be associated with increased risk and severity of infections, because this deficiency affects the functions of phagocytes, production of interferon, replication of viruses, and maturation of T lymphocytes

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Women and elderly individuals are particularly susceptible to developing RA, with the reasons for this yet to be fully understood (Lerner and Matthias 2015b)

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