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Concentrations of the peptide up to 500 ng/mL failed to increase proliferation of mouse C2C12 cells or primary human skeletal muscle myoblasts, failed to inhibit myoblast differentiation, and failed to activate the signaling responses previously attributed to it, even as mature IGF-1 and full-length IGF-1Eb produced robust responses in the same assays

Editorial 20 July 2021 Editorial: Levothyroxine Therapy in Patients With Hypothyroidism Alessandro Antonelli , Leonard Wartofsky and Paolo Miccoli 5,795 views 2 citations Editors 3 Alessandro Antonelli University of Pisa Paolo Miccoli Saint Camillus International University of Health and Medical Sciences Leonard Wartofsky School of Medicine, Georgetown University Impact Loading

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For patients in Miami who are exploring options beyond GLP-1 medications, this mechanism is clinically meaningful