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Unconjugated bilirubin may increase if the production increases (e.g., hemolysis) or hepatic uptake/conjugation decreases (e.g., Gilberts syndrome)

When to seek medical advice: Persistent vomiting or diarrhoea lasting more than 2448 hours contact GP or NHS 111 Symptoms suggestive of hypokalaemia (weakness, cramps, palpitations) contact GP Difficulty maintaining adequate fluid intake or reduced urine output contact GP or NHS 111 Chest pain, severe palpitations, or fainting call 999 or attend A&E Any concerns about medication side effects Patients should report suspected side effects via the MHRA Yellow Card Scheme (yellowcard.mhra.gov.uk or via the Yellow Card app)

2006;11(1) Adami LNG, Belardin LB, Lima BT, et al

Yes, GHK-Cu occurs naturally in human plasma, saliva, and urine, and was first isolated from human plasma in 1973