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The cardinal clinical manifestations of L2HGA include an insidious onset of disease beginning in childhood and includes developmental delay, epilepsy, and cerebellar ataxia

Three authors (MFMS, SB, AAK) assessed the selection bias (randomization and allocation concealment), performance bias (blinding of participant and health personnel), detection bias (blinding of outcome assessment), attrition bias (incomplete outcome data), reporting bias (selective reporting), and other biases (recall bias, transfer bias and etc.) independently

Neither is universally "better" they do different things

No RDA has been established for infants