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There are two medications you can take for heartburn and acid reflux: Proton pump inhibitors (PPIs), medications that significantly reduce stomach acid production for long-term use (although they should be weaned slowly off) H2 blockers, drugs that reduce stomach acid production by blocking histamine signals in the stomach lining, are better for occasional use While PPIs are generally more effective at providing 24-hour acid suppression and healing esophageal damage, they can increase the risk of nutrient deficiencies with long-term use