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Through ATF4-mediated integrated stress responses, cancer cells acquire not only drug persistence, ferroptosis sensitivity, and also metastatic phenotype 45,46,47

This effect of RRM1 silencing on erastin2-induced ferroptosis was specific: RRM1 silencing did not inhibit cell death in response to several mechanistically distinct small molecule inducers of apoptosis or other forms of non-apoptotic cell death that are not directly linked to intracellular GSH metabolism (Ko et al, 2019) (Fig S4A)

%), average path velocity (VAP), or curvilinear velocity (VCL), male ID was a random factor, and post-thaw sperm concentration and assessment time were added as co-variates

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