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On the other hand, MEDI0382 has been more extensively examined in multiple phase 2 RCTs, on diabetic obese patients, exhibiting significant reductions in blood glucose and body weight, 4850 alone or in combination with other antihyperglycemic agents (NCT02548585, NCT03444584, NCT03645421, NCT03244800, NCT03235050, NCT03745937, NCT03596177, NCT04019561)

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In a second study, researchers from the University of Texas Medical Branch, Houston, TX, used the TriNetX database to identify adults with obesity who underwent TAVR from January 2020 to January 2025