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Ocular hypertension triggers the production of pro-inflammatory cytokines by immune cells, which in turn drives the transformation of neuroprotective astrocytes into a neurotoxic A1-reactive phenotype, ultimately leading to RGC degeneration [45]

For instance, a study published in the Journal of Nutrition found that higher glutathione levels were associated with better insulin sensitivity in obese individuals

& Poluzzi, E

In glaucoma, mitochondrial Zn accumulation induces depolarization, increased permeability and fission, including mPTP opening and mitochondrial fragmentation occurring before retinal ganglion cell apoptosis 156