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Animal studies suggest a relatively short plasma half-life, but brain pharmacokinetics matter more for any cognitive effect

Nausea, vomiting and digestive complaints arise from the slowed gastric emptying and the strengthened satiety signal

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Specifically, eligible studies included participants (P) with a confirmed diagnosis of vitamin B12 deficiency, interventions (I) involving oral or sublingual vitamin B12 administration, comparators (C) using intramuscular supplementation, and outcomes (O) reporting changes in serum vitamin B12 or homocysteine levels