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Mercado, A., Broumand, V., Zandi-Nejad, K., Enck, A

(PubMed) Vinceti M, Filippini T, Wise LA, Rothman KJ

Because the risk of overdose increases as opioid doses increase, reserve titration to higher doses of Hydrocodone Bitartrate and Acetaminophen Tablets for patients in whom lower doses are insufficiently effective and in whom the expected benefits of using a higher dose opioid clearly outweigh the substantial risks