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Furthermore it was illustrated that multiple lysosomotropic compounds can redistribute the mannose 6-phosphate receptor from the trans-Golgi network to endosomes and concomitantly increase the secretion of lysosomal enzymes, resulting in a decline of intracellular lysosomal enzyme levels [36], which could further exacerbate the lysosomal dysfunction
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While peptides are a broad category of amino acid-based drugs that include well-known legal ones (like insulin and the GLP-1 weight loss drugs), the buzzand the FDA panelis focused on a bunch of them known by a string of letters and numbers
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