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G-protein coupled receptor binding of melatonin activates different signal cascades that can also affect gene transcription 37

Each of these 3 incretins have somewhat different effects, both at the gut level and via the brain, regarding reduced appetite, increased energy expenditure, nutrient storage and substrate utilization, insulin secretion, promotion of satiety, delay of gastric emptying, or reduced systemic inflammation

Excess visceral fat (the fat stored around your organs): Drives insulin resistance Increases inflammatory cytokines Raises cardiovascular risk Increases dementia risk Disrupts hormone signaling Suppresses growth hormone Having more visceral fat is particularly concerning, as it surrounds internal organs and is strongly linked to higher risks of chronic diseases compared to subcutaneous fat

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