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Although the degree of inflammation in OA is generally lower than in rheumatoid arthritis, synovial tissue can still exhibit marked hyperplasia and inflammatory cell infiltration ( Accompanying inflammation and mechanical damage, oxidative stress and multiple forms of cell death are deeply involved in the molecular mechanisms driving OA progression ( Figure 1 )

Melatonin supports normal immune function by helping maintain the activity of circulating natural killer cells

Because Acetyl L-Carnitine can more easily cross the blood-brain barrier, it is also called the neurological variant of carnitine

Similar findings were reported by Zhang Q